Browsing by Author "Polymenis, Michael"
Now showing items 1-20 of 59
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Tian, Lu (Texas A&M University, 2004-09-30)Epigenetic regulation is a mechanism by which heritable changes in gene expression are controlled by chromatin status rather than primary DNA sequence. Changes in chromatin structure affect accessibility of DNA elements ...
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Martinez, Elliott (2021-04-07)Phosphoinositides (PIPs) are phosphorylated derivatives of a membrane lipid called phosphatidylinositol that act as signaling molecules. These signaling molecules regulate hundreds of biological events ranging from growth, ...
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Tran, Tram Anh Thi (2009-05-15)T4 requires two proteins: holin, T (lesion formation and lysis timing) and endolysin, E (cell wall degradation) to lyse the host at the end of its life cycle. E is a cytoplasmic protein that sequestered away from its ...
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Park, Taehyun (2009-05-15)The fate of phage-infected bacteria is determined by the holin, a small membrane protein that triggers disruption of the membrane at a programmed time, allowing a lysozyme to attack the cell wall. S2168, the holin of phage ...
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Joseph, Sonia (2014-06-12)Tuberculosis is one of the leading causes of death due to infectious disease. The causative agent, Mycobacterium tuberculosis, is a facultative intracellular parasite with a slow regeneration rate. Though there is a decline ...
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Jhurry, Nema (2013-08-30)The speciation of iron in intact Jurkat cells and their isolated mitochondria was assessed using biophysical methods. [Fe4S4]^(2+) clusters, low-spin (LS) Fe^(II) heme centers, non-heme high-spin (NHHS) FeII species, ...
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Adase, Christopher A. 1981- (2012-11-20)Methyl-accepting chemotaxis proteins MCPs can bind one or more receptor- specific ligands. In the case of the Tar MCP of Escherichia coli (TarEc), a primary attractant ligand is aspartate. Its binding to the periplasmic ...
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Truong, Sandra Khavi (2017-02-01)The global population is increasing in size and economic affluence, and sustainable intensification of agriculture is necessary to meet projected fuel and food demands without increasing input of limited resources like ...
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Dasgupta, Ananya (2022-01-21)Cryptococcus neoformans, a heterothallic basidiomycete fungus, is one of the most invasive, opportunistic pathogens. It predominantly affects immunocompromised patients and is the most common cause of fungal meningitis ...
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Osborn, Benjamin Roy (2022-01-24)Phosphoinositides, the phosphorylated derivatives of phosphatidylinositol, are critical lipid signaling molecules that regulate a variety of intracellular processes. Sec14 and Sec14 domain proteins employ a heterotypic ...
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Ralph, Erik C. (2009-05-15)Despite a number of kinetic and spectroscopic studies, the chemical mechanisms of amine oxidation by flavoenzymes remain widely debated. The mechanisms of by Nmethyltryptophan oxidase (MTOX) and tryptophan 2-monooxygenase ...
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Jessen, Walter Joseph (Texas A&M University, 2006-04-12)In eukaryotes, the organization of DNA into chromatin is a primary determinant of gene expression. Positioned nucleosomes in promoter regions are frequently found to regulate gene expression by obstructing the accessibility ...
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Vargas Bautista, Carol M (2014-08-27)The pks genes are the largest antibiotic- encoding gene cluster in Bacillus subtilis and encode the Pks enzymatic complex that produces bacillaene. Bacillaene plays important roles in the fitness of B. subtilis during ...
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Sandoval Oporto, Pamela (2012-07-16)Here the ciliate protozoa Tetrahymena thermophila was used as a model system to study the DNA damage response. Tetrahymena enclose nuclear dimorphism, a polyploid somatic macronucleus (MAC), which is transcriptionally ...
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Guo, Jinbai (Texas A&M University, 2007-09-17)Cell cycle progression of Saccharomyces cerevisiae cells was monitored in continuous cultures limited for glucose or nitrogen. The G1 cell cycle phase, before initiation of DNA replication, did not exclusively expand when ...
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McLaughlin, Malcolm Thomas (2009-05-15)The presence of an unpaired copy of a gene during meiosis triggers the silencing of every copy of that gene in the diploid ascus cell of Neurospora crassa, a phenomenon called Meiotic Silencing. This phenomenon has two stages: ...
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Hoover, Evelyn 1991- (2012-04-26)Protein kinases are enzymes which phosphorylate other proteins and often play critical regulatory roles in cellular metabolism. We studied the effects of deletion of the TDA1 gene in Saccharomyces cerevisiae. TDA1 encodes ...
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He, Chong; Tsuchiyama, Scott K.; Nguyen, Quynh T.; Plyusnina, Ekaterina N.; Terrill, Samuel R.; Sahibzada, Sarah; Patel, Bhumil; Faulkner, Alena R.; Shaposhnikov, Mikhail V.; Tian, Ruilin; Tsuchiya, Mitsuhiro; Kaeberlein, Matt; Moskalev, Alexey A.; Kennedy, Brian K.; Polymenis, Michael (PLOS, 2014-12-18)The common non-steroidal anti-inflammatory drug ibuprofen has been associated with a reduced risk of some age-related pathologies. However, a general pro-longevity role for ibuprofen and its mechanistic basis remains ...
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Jordan, Rachel Alison (2015-12-07)The ribosomal DNA (rDNA) locus in Saccharomyces cerevisiae contains 150-200 tandem repeats of the ribosomal RNA genes. The rDNA acquires a special chromatin structure called silent chromatin that represses RNA Polymerase ...
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Niu, Lili (2009-05-15)A lot of things happen to proteins when Escherichia coli cells enter stationary phase, such as protein amount, post-translational modifications, conformation changes, and component of protein complex. Proteomics, which ...